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How Stress Affects Women’s Mental and Physical Health 
OHIOHEALTH

How stress affects women’s mental and physical health 


How stress affects women’s mental and physical health 

Stress is a familiar part of life, but it is much more than a feeling of being overwhelmed. For women, chronic stress can influence everything from hormones and heart health to digestion, sleep and immune function. Far from being just a mental or emotional state, stress creates true physical symptoms that can disrupt daily life and, if left unmanaged, lead to long-term health issues.

Laurie Hommema, MD, Senior Director of Well-Being at OhioHealth, and Sarah Vretas, LPCC, explain how ongoing stress affects women’s physical and mental health. Learn how stress emerges in the body, why women are particularly vulnerable and practical ways to manage it before it takes a physical toll.


woman not able to sleep

How does stress work?

Every animal has a stress response, or short burst of stress, to help them respond to challenging situations — including humans. However, modern life often exposes us to prolonged periods of stress, triggering a lingering physiological response. 

“Because humans have a developed brain, that stress response can last a lot longer because we think about it, we remember it, we talk about it,” Dr. Hommema says. “That keeps those stress hormones circulating much longer.”

One of these key hormones responsible for stress is cortisol. When its levels remain high, it can lead to a range of health effects. “There have been some studies that show that for women, cortisol can take a little longer to go back down to a baseline once it’s activated,” says Vretas. This means that the “wired” or activated state triggered by stress can stick around longer for women than men.

Many women report feeling both exhausted and restless. Vretas describes this common experience: “I’ll ask, ‘At the end of the day, do you feel wired but still tired? And they’ll answer, ‘Oh my goodness, yes, like I have so many thoughts. My mind is racing. I feel like I can’t calm down, but I am also so physically exhausted at the same time.’”

This prolonged hormonal response, combined with women’s natural hormonal fluctuations throughout life, can amplify the effects of stress. Women often shoulder unique caregiving roles and societal expectations, making it harder to set personal boundaries or tend to their own needs. “Women are more prone to the conditions which cause chronic stress, such as caregiving responsibilities or intimate partner violence,” notes Dr. Hommema. These all increase a woman’s risk for chronic stress-related issues. 


How to recognize symptoms of chronic stress

Physical and mental health are deeply connected. Chronic stress can manifest as persistent worry, irritability, burnout and mood swings — often triggering or worsening depression, anxiety and adjustment disorders. The effects of chronic stress rarely confine themselves to the mind, though, and can manifest in numerous physical ways. 

Early signs that stress might be affecting your health include headaches, disturbed sleep and trouble concentrating. “Some of the top symptoms we hear about are headaches, particularly tension-type headaches or an increase in migraines,” says Dr. Hommema. “Sleep disturbances are probably the most common, along with an inability to concentrate or make decisions.”

When stress lingers in the body longer term, it can impact your health in more significant ways:

  • Changes in cardiovascular health: Blood pressure may rise persistently, raising the risk of heart disease, heart attack and stroke. “High blood pressure is one of the most common stress-related health conditions we see,” explains Dr. Hommema.

  • Weakened immune system: Fatigue compounds physical symptoms and can not only increase how often you get sick, but also compromise your immune system’s ability to function well. “Stress can worsen existing health conditions, making management of chronic illnesses such as diabetes or autoimmune disorders more challenging,” says Vretas.

  • Musculoskeletal pain: Many people carry stress in their muscles, leading to pain in the shoulders, back or neck.

  • Digestive problems: Stress can ramp up stomach acid and gut sensitivity, resulting in heartburn, stomach aches or aggravating IBS.

  • Hormonal and reproductive health: Stress and shifting hormone levels can disrupt menstrual cycles, amplify PMS symptoms or worsen perimenopausal complaints. Pregnant and postpartum women are especially vulnerable to mood and physical symptoms.

Ongoing stress can also cascade, creating a compounding cycle: lack of rest reduces your coping skills, which further impairs sleep, immune function and emotional regulation. 


Woman stuggling to do her work, stressed, tired

Recognizing the impact and when to seek help

Recognizing how stress shows up — physically and emotionally — can help you address issues early. If you notice recurring symptoms or you feel you’re no longer able to manage your daily responsibilities, it’s time to speak to your healthcare provider. 

Sometimes identifying stress as the source of physical symptoms can be difficult. “The established connection between stress and physical health requires increased recognition and discussion within healthcare settings,” says Vretas. “Healthcare providers must facilitate open communication about stress and its health impacts without judgment.” Have an open dialogue about your stress with your provider and advocate for what you need. 


Woman deep breathing

Proactive steps for stress management and self-care

Navigating stress is inevitable, but its effects don’t have to be. Prioritizing self-care is crucial for your health, especially for women balancing caregiving, work and personal demands. Dr. Hommema makes a distinction between passive stress relief (like watching TV, which may only provide temporary distraction) and active stress management. 

Practices like meditation, deep breathing, exercise, gentle yoga and meaningful social connection can “actively shut down the fight-or-flight response and provide long-term benefits.” Building those habits before you reach a crisis point is important. It’s far easier to fall back on established routines than to start something new when you’re already overwhelmed. 

Vretas encourages a simple but vital check-in — ask yourself: “Am I being a friend to myself right now? Am I showing up for myself in the way that I would show up for one of my best friends?”

For many women, self-care may feel like an indulgence or even provoke guilt. But prioritizing your own well-being is essential not just for you, but also for those you support. Self-care allows you to show up more fully for others and provides resilience in the face of life’s challenges.


Woman doing yoga

Safeguard yourself from chronic stress

Stress in women isn’t just a fleeting emotion — it’s a whole-body experience that can affect your heart, hormones, immune system, digestion and more. Life stages like pregnancy, perimenopause, and caregiving can heighten vulnerability, and physical symptoms may be the first signal that something’s off. By recognizing the signs, seeking help when necessary, and weaving stress-management into your routine, it’s possible to safeguard both physical and mental health.

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